Particles on the move: Intracellular trafficking and asymmetric mitotic partitioning of nanoporous polymer particles

Y Yan; ZW Lai; RJA Goode; J Cui; T Bacic; MMJ Kamphuis; EC Nice; F Caruso

Journal article

Particles on the move: Intracellular trafficking and asymmetric mitotic partitioning of nanoporous polymer particles

Y Yan, ZW Lai, RJA Goode, J Cui, T Bacic, MMJ Kamphuis, EC Nice, F Caruso

ACS Nano | AMER CHEMICAL SOC | Published : 2013

DOI: 10.1021/nn401800u

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Abstract

Nanoporous polymer particles (NPPs) prepared by mesoporous silica templating show promise as a new class of versatile drug/gene delivery vehicles owning to their high payload capacity, functionality, and responsiveness. Understanding the cellular dynamics of such particles, including uptake, intracellular trafficking, and distribution, is an important requirement for their development as therapeutic carriers. Herein, we examine the spatiotemporal map of the cellular processing of submicrometer-sized disulfide-bonded poly(methacrylic acid) (PMASH) NPPs in HeLa cells using both flow cytometry and fluorescence microscopy. The data show that the PMASH NPPs are transported from the early endosome..

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University of Melbourne Researchers

Frank Caruso Author

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Grants

Awarded by Australian Research Council under the Australian Laureate Fellowship

Awarded by Discovery Early Career Researcher Award

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Discovery Early Career Researcher Award (Y.Y., DE130100488) schemes and by the National Health and Medical Research Council (NHMRC) Program Grant 487922 (F.C.).